CLOZAPINE N-OXIDE
- Product Name
- CLOZAPINE N-OXIDE
- CAS No.
- 34233-69-7
- Chemical Name
- CLOZAPINE N-OXIDE
- Synonyms
- CLOZAPINE N-OXIDE;Clozapine Impurity 16;Clozapine N-Oxide imp;Clozapine N-oxide (CNO);Clozapine N-oxide solution;Clozapine N-oxide Methanol Adduct;Clozapine N-oxide dihydrochloride NEW;Clozapine N-oxide (4-oxido-piprazinyl);Clozapine N-Oxide (1.0 mg/mL in Methanol);MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS
- CBNumber
- CB4759216
- Molecular Formula
- C18H19ClN4O
- Formula Weight
- 342.82
- MOL File
- 34233-69-7.mol
CLOZAPINE N-OXIDE Property
- Melting point:
- 190-248°C
- Flash point:
- 9℃
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- Soluble in DMSO.
- form
- powder
- pka
- 6.86±0.20(Predicted)
- color
- Yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- OGUCZBIQSYYWEF-UHFFFAOYSA-N
Safety
- Hazard Codes
- Xn,T,F
- Risk Statements
- 22-36/37/38-39/23/24/25-23/24/25-11
- Safety Statements
- 26-36-45-36/37-16-7
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- HP1760000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29335990
N-Bromosuccinimide Price
- Product number
- C0832
- Product name
- Clozapine N-oxide
- Packaging
- 5mg
- Price
- $232
- Updated
- 2024/03/01
- Product number
- J67235
- Product name
- Clozapine N-oxide, 99%
- Packaging
- 5mg
- Price
- $186
- Updated
- 2024/03/01
- Product number
- 16882
- Product name
- Clozapine N-oxide
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 16882
- Product name
- Clozapine N-oxide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- SML2304
- Product name
- Clozapine N-oxide hydrochloride
- Purity
- ≥98% (HPLC), Water soluble Clozapine N-oxide
- Packaging
- 5mg
- Price
- $225
- Updated
- 2024/03/01
CLOZAPINE N-OXIDE Chemical Properties,Usage,Production
Description
Clozapine-N-oxide (34233-69-7) is a clozapine?metabolite1?which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2?May be used to control grafted human pluripotent stem cell-derived neurons engineered to express DREADDs.3,4??Numerous other applications.5,6
Chemical Properties
Yellow Solid
Uses
Clozapine N-oxide has been used:
- for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
- for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
- in behavioral testing in mice and for stimulating (HEK293) cells
Uses
A 5-HT2 antagonist. A major metabolite of clozapine that can be monitored by HPLC. Possesses little or no activity towards serotonin receptors
Definition
ChEBI: Clozapine N-oxide is a dibenzodiazepine.
General Description
Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.
Biochem/physiol Actions
5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.
storage
Room temperature (desiccate)
References
1) Eiermann?et al.?(1997),?The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine; Br. J. Clin. Pharmacol.,?44?439 2) Armbruster?et al.?(2007),?Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand; Proc. Natl. Acad. Sci. USA,?104?5163 3) Chen?et al.?(2016),?Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease; Cell Stem Cell,?18?817 4) Vazey and Aston-Jones (2014),?Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson’s disease: J. Clin. Invest.,?124?2858 5) Gomez?et al.?(2017)?Chemogenetics revealed: DREADD occupancy and activation via converted clozapine; Science?357?503 6) Marcinkiewcz?et al. (2016)?Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala; Nature?537?97
CLOZAPINE N-OXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
CLOZAPINE N-OXIDE Suppliers
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View Lastest Price from CLOZAPINE N-OXIDE manufacturers
- Product
- Clozapine Noxide 34233-69-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-10-07
- Product
- Clozapine N-oxide 34233-69-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Clozapine N-oxide 34233-69-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08